Xu Lab at the McGovern Medical School Functional Cancer Genomics

News

Zhichao has accepted the offer from Houston

Zhichao has accepted the appointment to the faculty of McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston), with the rank of Assistant Professor, on the tenure track, in the Department of Biochemistry and Molecular Biology. Zhichao is expected to start his new journey on April 1st, 2025.

Paper accepted at Journal of Experimental Medicine
Paper accepted at Journal of Experimental Medicine

The previous Biorxiv paper titled “A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis” is accepted at the Journal of Experimental Medicine. In collaboration with Dr. Monte Winslow at Stanford, this work uncovered the function of STAG2 in a mouse lung cancer model. Dr. Xu contributed to the genome conformation profiling and data analysis, and was responsible for writing and preparing the figures for this section of the manuscript.

Paper submitted to BioRxiv
Paper submitted to BioRxiv

Our manuscript, “Heterogeneity in chromatin structure drives core regulatory pathways in B-cell Acute Lymphoblastic Leukemia,” is submitted to BioRxiv and Nature Genetics. In this work, Dr. Xu profiled over 50 primary pediatric B-ALL samples using Hi-C, ATAC-seq, and RNA-seq, and identified distinct 3D genome structures across transcriptional subtypes linked to B-cell developmental stages.

Paper submitted to BioRxiv
Paper submitted to BioRxiv

Our manuscript, “A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis,” is submitted to BioRxiv and the Journal of Experimental Medicine. In collaboration with Dr. Monte Winslow at Stanford, this work uncovered the function of STAG2 in a mouse lung cancer model. Dr. Xu contributed to the genome conformation profiling and data analysis, and was responsible for writing and preparing the figures for this section of the manuscript.